Synthesis, Structure and Antitumour Properties of a New 1,2-Propylenediaminetetraacetate-Ruthenium(III) Compound

نویسندگان

  • R. Vilaplana
  • M. A. Romero
  • M. Quirós
  • J. M. Salas
  • F. González-Vílchez
چکیده

A novel complex formed by ruthenium (III) and the sequestering ligand 1,2-propylenediaminetetraacetic acid (PDTA) has been synthetized and characterized. The structure of the monomeric compound, studied by X-ray diffraction , shows an almost symmetric octahedral geometry around the metal ion, with two chlorine atoms in a cis conformation. The antitumour activity against a variety of murine and human cancers is reported.

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عنوان ژورنال:
  • Metal-Based Drugs

دوره 2  شماره 

صفحات  -

تاریخ انتشار 1995